Management of Recurrent or Metastatic Retroperitoneal Soft-Tissue Sarcomas
D. Damianov, Y. Asenov, P. Kurtev, N. Penkov, B. Korukov, P. Gerzilov, T. Sedloev, B. GolemanovOriginal article, no. 5, 2014
Retroperitoneal soft-tissue sarcomas remain a serioustherapeutic problem.The aim of the study is to define the optimal treatmentstrategy of patients with locally recurrent or metastaticretroperitoneal soft-tissue sarcomas.
Material and methods: A retrospective study was performed.Between 2001 and 2013, 89 patients with retroperitoneal softtissue sarcomas were surgically treated in the UniversityHospital "Queen Joanna - ISUL" and the Specialized Hospitalfor Active Treatment in Oncology - Sofia. Clinicopathologicaldata were investigated with SPSS-19.
Results: The mean time of onset of the first and second relapseof sarcomas was 23 and 13 months, respectively. Over 40% ofthe studied patients underwent more than one operationbecause of recurrence. Ability of radical extirpation of thetumour decreased with each subsequent relapse. The 5-yearsurvival rate was 60% for patients with primary combinedradical resection versus 28% for patients with partial resection.In the presence of metastatic lesions the 3-year survival ratewas only 22%.
Conclusion: Local recurrences, the presence of distantmetastases and the ability of radical extirpation are the mainlong-term prognostic factors.
Material and methods: A retrospective study was performed.Between 2001 and 2013, 89 patients with retroperitoneal softtissue sarcomas were surgically treated in the UniversityHospital "Queen Joanna - ISUL" and the Specialized Hospitalfor Active Treatment in Oncology - Sofia. Clinicopathologicaldata were investigated with SPSS-19.
Results: The mean time of onset of the first and second relapseof sarcomas was 23 and 13 months, respectively. Over 40% ofthe studied patients underwent more than one operationbecause of recurrence. Ability of radical extirpation of thetumour decreased with each subsequent relapse. The 5-yearsurvival rate was 60% for patients with primary combinedradical resection versus 28% for patients with partial resection.In the presence of metastatic lesions the 3-year survival ratewas only 22%.
Conclusion: Local recurrences, the presence of distantmetastases and the ability of radical extirpation are the mainlong-term prognostic factors.
