The Role of Collagen Metabolism in the Formation and Relapse of Incisional Hernia
P. Radu, M. Brătucu, D. Garofil, V. Goleanu, F. Popa, V. StrâmbuGeneral reports, no. 3, 2015
Despite the continuous development of synthetic prostheticmeshes and their wide use, recurrent incisional hernias stillappear in 5 to 20% of cases, with a linear incidence curve overthe years, suggesting a multifactorial process rather than asimple failing technical repair as the underlying cause. Recent molecular biological research provide increasing evidence of connective tissue alterationssuch as a defective wound healingwith impaired scarring process in patients with incisional hernia. Although there are some promising results, at present, in-depth understanding of the pathophysiological mechanismsand of the role that collagens play in the development and recurrence of incisional hernia is rather scarce. The aim of thissystematic review is to summarize and evaluate the biochemical mechanisms involved in incisional hernia formation andrecurrence, with a primary focus on collagen I to III ratio. Also, the consequences for surgical practice are discussed.
