Serum C-reactive Protein and White Blood Cell Level as Markers of Successful Percutaneous Drainage of Acute Sterile Peripancreatic Fluid Collection
R. Kotán, P. Sápy, S. Sipka, L. Damjanovich, D. Ágoston Kovács, A. Csiszko, K. Balog, Z. SzentkeresztyOriginal article, no. 1, 2015
Background: Percutaneous drainage is not a widely used therapeuticmethod recently for evacuating peripancreatic sterilefluid collections in patients with severe acute pancreatitis.However, many clinical studies have proved its positive effects.Aim: We tested the changes in serum laboratory parameters:C-reactive protein (CRP), complement factor 3-4 (C 3-4),tumor necrosis factor a (TNF-a), amylase, lipase and whiteblood cell (WBC) count in patients treated by percutaneousdrainage.Patients and Methods: 10 patients with severe acute pancreatitiswith peripancreatic fluid collection were monitored.Laboratory parameters and the amount of drained fluid weremeasured on the 1st, 5th and 10th day. Statistical analysis wasperformed by using Statistica for Windows (Version 7.0)software. P values less than 0.05 were considered statisticallysignificant.Results: We found significant positive correlation betweenthe CRP and WBC serum level and volumes of the drainedfluid. We used these parameters as markers of successfulpercutaneous drainage in case of patients with severe acutepancreatitis complicated with sterile peripancreatic fluid.There was no significant change in the levels of C 3-4,tumor necrosis factor-ÃŽ+-, amylase and lipase.Conclusions: Monitoring of serum CRP and WBC levels maybe recommended for follow up after percutaneous drainageof peripancreatic fluid.Abbreviations: CRP: C-reactive Protein TNFÃŽ+-: TumourNecrosis Factor a, C3-4: Complement 3-4 WBC: WhiteBlood Cell CT: Computed Tomography
