Multiple Polyps and Colorectal Cancer

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Multiple Polyps and Colorectal Cancer

M. Alecu, L. Simion, N.D. Straja, E. Brătucu
Original article, no. 3, 2014
Introduction: Malignant degeneration as a possible course ofevolution of colorectal polyps renders their diagnosis andtherapeutic management a prophylactic act in the preventionof colorectal cancer (CRC).Material and Method: The study was conducted over a periodof 3 years (2008-2011), during which 1,368 colonoscopieswere performed in our service. The aim of the study was toidentify patients presenting multiple colorectal polyps andto determine their risk factors for developing CRC, as wellas to establish the appropriate therapeutic conduct.Results: Presence of multiple polyps was recorded in over40% of the patients identified with colorectal polyps of anykind. Dysplastic modifications observed during thehistopathology exam presented a high incidence in the caseof patients with multiple polyps, ranging from low-gradedysplasiato incipient CRC.Conclusions: Dysplastic modifications and carcinomatous fociwere identified mostly among patients with multiple polyps.Only benign lesions or in situ carcinomas benefited fromendoscopic treatment, poorly differentiated carcinomas orthose invading the submucosa being treated by conventionalsurgery. Patients diagnosed with colorectal polyps require arigorous post-therapy follow-up protocol, able to identify anyeventual polyposis recurrence.