Morphological and Immunohistochemical Criteria of Tissue Response to Radiotherapy in Rectal CancerS. Ionescu, E. Brătucu, S. Zurac, F. Staniceanu, Tr. Pătraşcu, Tr. Burcoş, V. Herlea, D. Degeratu, I. Popa,D. Cristian
Original article, no. 5, 2013
Aim: Given the context that rectal tumours respond to acertain degree to radiotherapy, a necessity arises for estimatinga tumourÃ¢Â€Â™s capacity to react to radiation from the very momentof diagnostic biopsy.Material and Methods: We have histologically and immunohistochemicallyanalysed tissues coming from 52 patientswith rectal adenocarcinomas.Results: Of the studied parameters, the ones presenting significantvariation under radiotherapy in terms of statistics(p 0.05) were: colloid type (p=0.001), EGFR in the tumour(p=0.00045), EGFR in the normal epithelium (p=0.0017),VEGF in the tumour (p=0.0132) and VEGF in the tumourstroma (p=0.030).Conclusions: Our study follows the same trends as the medicalliterature we have consulted regarding the variation of EGFRand VEGF with radiotherapy, and the distinct note of our studyrelies in the observation that normal stroma in case of rectal tumors also reacts to radiotherapy, sometimes more aggressivelythan the tumor itself, especially in which concerns the nerveand muscle fibers.