GSTM1 GSTT1 and GSTP1 in Patients with Multiple Breast Cancers and Breast Cancer in Association with another Type of Cancer

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GSTM1 GSTT1 and GSTP1 in Patients with Multiple Breast Cancers and Breast Cancer in Association with another Type of Cancer

D. N. Chirilă, O. Bălăcescu, R. Popp, A. Oprea, N. A. Constantea, Ș. Vesa, C. Ciuce
Original article, no. 5, 2014
Introduction: breast cancer has the highest incidence in women.Glutathione S-transferases (GSTs) are a large group of enzymesinvolved in the metabolism of xenobiotics. The members ofthis gene superfamily are involved in the development ofmultiple cancers.Objectives: the aim of the study was to see whether theGSTM1, GSTT1 and GSTP1 genetic polymorphisms are riskfactors for patients diagnosed with multiple malignancies, of which at least one is located in the breast.
Materials and Methods: in the period between 2005 and 2012,of the 520 patients diagnosed with breast cancer, 69 hadmultiple primitive malignant tumors, of which at least one waslocalized in the breast. The research on GSTM1, GSTT1 andGSTP1 genotypes consisted of 59 patients diagnosed withmultiple breast cancers or with breast cancer in association with another type of cancer, compared with a group of healthycontrols.
Results: in the subgroup of patients with breast cancer inassociation with another type of cancer, the GSTM1 nullgenotype was present in 61.2% of patients, compared to 29% ofcontrols; the subgroup of metachronous breast cancers, the presence of any of the GSTT1 or GSTM1 null genotypes wasstatistically significantly different from that of controls (65.2%vs. 28.5%); in the subgroup with synchronous cancers, the GSTM1 null genotype was found in 66.6% of patientscompared to 9% for the controls, and the presence of any nullgenotype (GSTM1 and GSTT1) was also statistically significant in the case group.
Conclusions: the GSTM1 null genotype is a risk factor forsynchronous breast cancers and for breast cancer associatedwith extramammary cancer; the presence of null genotypes(GSTM1 or GSTT1) is a risk factor for multiple breast cancer(bilateral or synchronous); the GSTT1 null genotype and theheterozygous variant allele (Ile105Val) and homozygous variantallele (Val105Val) of GSTP1 are not risk factors for the cases studied.