GSTM1 GSTT1 and GSTP1 Genetic Variants in Multiple Urologic Cancers

Introduction: Glutathione S-transferases (GSTs) are phase 2enzymes responsible for catalyzing the biotransformation of awide variety of electrophilic compounds, having a crucial rolein the detoxification of active metabolites of procarcinogens produced by phase 1 reactions, tying them to glutathione and promoting their excretion in the urine. Objectives: we evaluated GSTM1, GSTT1 and GSTP1 genotypesin patients diagnosed with multiple malignancies, ofwhich at least one was found in the prostate, bladder orkidney. Materials and methods: GSTM1, GSTT1 and GSTP1 genotypeswere genetically assessed in 34 patients with multiple urologiccancers and 23 patients with urologic cancer associated with another type of cancer. Results: in the group of patients with multiple urologic cancers,GSTT1 null genotype was found in 26.4% of patientscompared to 0% in controls, 82.35 % of patients and 47% of witnesses carried at least one GSTM1 or GSTT1 null genotype, and in the group with different cancers, GSTM1 null genotype was found in 52.1% of patients compared to 4.3% witnesses in the control group; GSTT1 null genotype wasfound in 34.7% of patients compared to 4.3% of witnesses, atleast one GSTM1 or GSTT1 null genotype was found in73.9% of patients compared to 8.6% of controls. Conclusions: GSTT1 null genotype is a risk factor for patients with more primitive urologic malignancies (bladder, prostate and kidney); GSTM1 or GSTT1 null genotype is more frequent in patients with multiple urologic tumors; GSTM1and GSTT1 null genotypes are risk factors in patients with different types of cancer, with at least one affecting the urinarysystem.

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