Early Dynamics of Leptin Plasma Level in Surgical Critically ill Patients. A Prospective Comparative Study

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Early Dynamics of Leptin Plasma Level in Surgical Critically ill Patients. A Prospective Comparative Study

I. Grigoraş, D.D. Branisteanu, D. Ungureanu, D. Rusu, I. Ristescu
Original article, no. 1, 2014
Background: Leptin (LPT), a hormone secreted by adipocytes,plays a role in inflammation and infection. Our study aimed tocharacterize the early dynamics of LPT in comparison withCRP and IL-6 during systemic inflammatory response syndrome(SIRS) and sepsis in surgical patients.Methods: Sixty patients were assigned into 3 equal groups:SIRS (SI) group with major abdominal elective surgery;sepsis (SE) group with community-acquired complicatedintra-abdominal infection and controls (C). LPT, CRP andIL-6 were measured initially in all groups and repeated ingroups SI and SE within 5 days after surgery (9 samples â€"4 day1, 2 day2, 1 next 3days).Results: LPT increased at 12-24 hours in SI group, but stayedwithin normal range in SE group. CRP and IL-6 had highervalues in SE group versus SI group with an early peak forIL-6 and a late peak for CRP.Conclusions: LPT has a different early dynamics during SIRSand sepsis. LPT measurement in association with CRP orIL-6 may be useful in the differential diagnosis and prognosisof surgical critical illness at different time courses.