Laparoscopic Sleeve Gastrectomy Improves Reproductive Hormone Levels in Morbidly Obese Males - A Series of 28 Cases

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Laparoscopic Sleeve Gastrectomy Improves Reproductive Hormone Levels in Morbidly Obese Males - A Series of 28 Cases

R. Mihalca, C. Copăescu, A. Sirbu, S. Florea, S. Martin, C.G. Barbu, S. Fica
Original article, no. 2, 2014
Background: Obese males frequently present with low androgenlevels that may improve after weight loss achieved by bariatricsurgery. Laparoscopic sleeve gastrectomy (LSG) has been usedoften in the last decade as treatment for morbid obesity. Theaim of this study was to evaluate modifications in the malereproductive hormone profile after LSG.Patients and Methods: The prospective study included 28 maleswith body mass index (BMI) 35 kg m2 who underwent LSG.Total Testosterone (TT), Sex Hormone Binding Globulin(SHBG) and Luteinizing hormone (LH), together withbiochemical and anthropometric data, were evaluated atbaseline and after LSG.Results: Baseline patients had a mean BMI of 50.10 (Â+-11.19)kg m2, SHBG 23.37 (+-17.47) nmol L, LH 3.83 (+-1.76)mUI ml and TT 8.31 (+-3.24) nmol L. After LSG, patientsshowed a mean BMI of 35.87 (+-7.02) kg m2 (p 0.001),SHBG 37.81 (Â+-18.95) nmol L (p 0.05), LH 4.76 (+-2.49)mUI ml (p 0.05), whereas mean TT was 12.7 (Â+-3.8) nmol L(p 0.001). The percentage of excess body weight loss (%EBL)was 43.07 (+-9.56) and metabolic syndrome prevalencedecreased significantly from 75% to 25% (p 0.001).Conclusions: Beyond BMI loss, LSG significantly improvedreproductive hormone levels in morbidly obese males.